We begin with the detailed molecular and cellular characterization of human disease and non-diseased tissue to identify the critical biochemical mediators that are causative in disease. The biochemical analysis of human disease tissue has allowed the unraveling of the molecular mechanisms that initiate and maintain the diseased fibrotic process. These investigations have been successful in leading to the identification of novel pathways capable of modulating human fibrotic disease. This work resulted in the company identifying new disease-modulating targets to treat fibrosis and that anti-TNF therapy can be effective to prevent progression of the disease.
Dupuytren’s disease can result in significant irreversible contracture of the fingers and is estimated to afflict ~4% of the US and EU populations.